★★★★★VerifiedDecember 2022
At age 76, I feel my absolute best when I take Vital Factors. It provides me the energy I need and the mental alertness to accomplish my goals on a daily basis. Also helps me accomplish my exercise goals.
Judith H.
4.7 from 16 verified reviews
Energy support — without caffeine
Feel clearer, steadier, and less drained — without caffeine.
A doctor-designed effervescent drink with NAD support, amino acids, antioxidants, B vitamins, and vitamin D3 — energy, focus, and healthy aging on a simple 5-on / 2-off routine, without the stimulant crash.
Save 15% · Free shipping · Cancel anytime · 60-day money-back guarantee
- 0%
- Daily Value B12
- 0 mg
- Caffeine
- 0
- Doctor-designed since
- Doctor-designed
- No caffeine
- 40 tablets per box
- Free shipping on subscriptions
- 60-day money-back guarantee
- MDR since 1984
What changes
Three things to expect.
8,333% DV B12
Steadier daytime energy
Methylcobalamin B12 (8,333% DV) and a full B-complex provide the cofactors involved in normal cellular metabolism — the way your body actually makes energy.
Amino-acid blend + D3
Clearer focus
An amino-acid blend plus B-vitamins and vitamin D3 supports focus through nutrition rather than stimulation, so focus doesn't come with a crash.
Zero caffeine · zero sugar
Steady afternoon energy
No caffeine, no sugar, no synthetic stimulants. The only thing you'll feel coming down at 2 PM is your second glass of water.
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Choose how to start
Subscribe and save — or just one box.
Most people subscribe to save 15% with free shipping every month — and cancel anytime in two clicks, no phone call. Prefer to test it first? Try a single box. No surprises either way.
Free shipping on subscriptions · 60-day money-back guarantee · Ships in 24h
How it works
Built for steady focus, not the buzz.
Two effervescent tablets in a glass of water before a meal. Five days on, two days off — that's the entire routine.
- 01
Drop two tablets in 8 oz of water
Stir, let them dissolve, drink. The effervescent format puts the actives into solution your stomach can absorb directly.
- 02
5 days on, 2 days off
Take your two tablets Monday through Friday, then take a two-day break on the weekend. The rhythm keeps the body responsive.
- 03
Give it about 30 days
Most customers report feeling steadier energy and clearer focus inside the first month of consistent use.
Why this is different
It's not an energy drink. It's complete nutrition.
Energy drinks borrow energy from tomorrow with caffeine and sugar. VitalFactors does the opposite — it provides nutrients involved in how your cells actually produce energy.
Feature
VitalFactors
Caffeinated energy drink
CaffeineNone80–300 mg
SugarZeroOften 25–55 g
B12 (Methylcobalamin)200 mcg · 8,333% DVOften synthetic cyanocobalamin or none
Amino acids for recovery
Antioxidant defense (Resveratrol, SOD)
Crash potentialNoneHigh
Doctor-formulated
What you're actually drinking
The energy stack, in plain English.
No mystery proprietary blends. Here are the ingredients on the label that do the work — full quantities are on the Supplement Facts panel below.
01
Nicotinamide Riboside Chloride
NAD⁺ precursorA clinically studied NAD⁺ precursor — supports cellular NAD⁺ levels involved in how cells make energy.
02
CoQ10
Coenzyme central to mitochondrial energy production — supports cellular energy.
03
Amino-acid blend
L-Arginine, Glycine, L-Glutamine, L-Lysine, L-OrnithineA balanced amino-acid stack traditionally used by athletes for recovery and lean muscle support.
04
Vitamin B12
Methylcobalamin · 8,333% DVSupports focus and red blood cells, which carry oxygen to cells.
05
B-complex panel
B1, B2, B6, Biotin, Folic Acid, Pantothenic AcidA complete B-vitamin panel involved in normal cellular metabolism and energy production.
06
Vitamin D3
CholecalciferolSupports bone, mood, and immune health — the form your body uses most efficiently.
07
Magnesium
Trimagnesium DicitrateMineral involved in muscle and nerve function — supports steady daytime energy.
Supplement Facts
The full label, exactly as printed.
Serving size 2 tablets · 20 servings per container. Tap below to see the complete panel with every ingredient, amount, and % Daily Value.
Customer reviews
From people who were tired of being tired.
Real reviews from verified MDR customers — pulled from the live store, filtered for energy-related feedback.
4.7/ 5★★★★★from 16 verified customers
★★★★★VerifiedMay 2022
Product easy to use, tablet dissolves easier now, and gives me more energy and focus just after a few days of starting it!
Happy G.
★★★★★VerifiedJuly 2022
I tried out the Vital Factors to see if I could tell any difference in how I felt. I take several supplements already. After a week I could tell that I had more energy and stamina than I had been having which is one of the reasons I wanted to try it. I am now on auto-ship and looking to see if the things it says it will do actually do. But just being able to have the needed energy will keep me taking it.
Kathleen H.
★★★★★VerifiedMarch 2022
Great product! I take it in the morning before exercising and it gives me energy without the side effects other supplements do. I did prefer the old formula, as the color was purple instead of the current color, orange.
Aaron H.
★★★★★VerifiedMay 2020
I’ve been using this product for years and have never been disappointed. The product does what it says,, gives energy and vitality.
Thomas S.
★★★★★VerifiedMarch 2019
Ever since I started taking these, I feel as though I have so much more energy!
Lindsay S.
Made by Medical Doctors' Research
Made by physicians, since 1984.
Medical Doctors' Research has been formulating clinician-grade supplements for over forty years. VitalFactors is the formula MDR doctors put together for adults who want to feel like themselves through the afternoon — without leaning on caffeine.
- 01Founded in 1984
- 02Doctor-formulated
- 03Manufactured to cGMP standards
- 04Used by physicians and their patients
Dr. Lisa Learn
Board-Certified Plastic & Reconstructive Surgeon
"I take VitalFactors and give it to my patients."
Safety
Nutrition, taken seriously.
VitalFactors is a nutritional formula made of vitamins, minerals, amino acids, and well-studied botanicals — not a drug — taken on a 5-on / 2-off cycle per the label. For most healthy adults it's a straightforward addition to a routine.
If you take prescription medications — especially blood thinners, diabetes medications, or hormone therapies — ask your physician or pharmacist before use. If you have kidney, liver, or gastrointestinal disease, or if you're pregnant or nursing, consult your physician first.
Contains soy isoflavones (a plant-based polyphenol). Free of gluten, dairy, eggs, fish, shellfish, tree nuts, peanuts, and animal ingredients.
Risk-free to try
One box. No traps.
Cold-traffic landing pages on the internet are notorious for sneaky checkouts. We don't do that. Here's exactly what you get.
Free shipping on subscriptions
Subscriptions ship free in the US, usually within 24 hours; one-time orders ship for $6.95.
60-day money-back guarantee
Don't feel a difference? Send it back within 60 days for a full refund of the product cost.
Cancel anytime
If you choose a subscription, cancel or pause from your account in two clicks. No phone call, no fees.
FAQ
Energy questions, answered.
Most customers report feeling a difference in steadier daytime energy and clearer focus within the first few weeks of consistent use. Because VitalFactors works through nutritional support rather than a stimulant, the change builds gradually — but it's real, and it doesn't crash. If you don't feel a difference inside 60 days, send the box back.
Ready when you are
One box. One month. See how the afternoons feel.
Most people start with one box, finish it, and then decide. We make that easy on purpose.
Free shipping on subscriptions · 60-day money-back guarantee · Cancel anytime.