★★★★★VerifiedDecember 2022
At age 76, I feel my absolute best when I take Vital Factors. It provides me the energy I need and the mental alertness to accomplish my goals on a daily basis. Also helps me accomplish my exercise goals.
Judith H.
4.7 from 16 verified reviews
NAD support · cellular health
NAD support in a simple effervescent drink.
VitalFactors delivers NAD-supporting nutrition with amino acids, antioxidants, B vitamins, vitamin D3, and resveratrol — in an effervescent formula built for cellular health support on a 5-on / 2-off routine.
Save 15% · Free shipping · Cancel anytime · 60-day money-back guarantee
- 0%
- Daily Value B12
- 0 mg
- Caffeine
- 0
- Doctor-designed since
- Doctor-designed
- No caffeine
- 40 tablets per box
- Free shipping on subscriptions
- 60-day money-back guarantee
- MDR since 1984
What is NAD support?
NAD in plain English.
NAD+ (nicotinamide adenine dinucleotide) is a coenzyme your cells use for energy production. It sits at the center of how your body actually makes and spends energy.
NAD+ is a focus of ongoing nutrition research into how cells produce energy. (Imai & Guarente, Trends in Cell Biology, 2014)
"NAD support" means giving the body the precursor nutrients it uses to make NAD+. VitalFactors uses Nicotinamide Riboside Chloride — a clinically studied NAD+ precursor — alongside other cofactors involved in cellular energy biology.
VitalFactors is a nutritional formula taken on a 5-on / 2-off cycle. It's not a drug and not a treatment for any condition. It's the same kind of foundational nutrition routine as taking a vitamin — with ingredients chosen for cellular health support.
What the formula supports
A complete cellular-health stack — not just NAD.
01
NAD support
Nicotinamide Riboside Chloride is a precursor your cells use to make NAD⁺. CoQ10 and Niacinamide are layered alongside as cofactors involved in mitochondrial energy biology.
02
Antioxidant defense
resVida® Resveratrol, Extramel® SOD, EGCG green-tea polyphenols, and grape seed proanthocyanidins support antioxidant defense against oxidative stress.
03
Amino acid recovery
L-Arginine, Glycine, L-Glutamine, L-Lysine, and L-Ornithine — a balanced amino-acid stack used by athletes for recovery and lean muscle support.
Choose how to start
Subscribe and save — or just one box.
Most people subscribe to save 15% with free shipping every month — and cancel anytime in two clicks, no phone call. Prefer to test it first? Try a single box. No surprises either way.
Free shipping on subscriptions · 60-day money-back guarantee · Ships in 24h
Why this is different
An NAD capsule is one ingredient. This is the whole stack.
Most NAD products are a single capsule with one precursor and a markup. VitalFactors layers the NAD precursor inside a complete nutrition formula — at a per-serving cost that's usually lower than capsule-only alternatives.
Feature
VitalFactors
Typical NAD capsule
NAD⁺ precursorNicotinamide Riboside ChlorideNMN or NR alone
Resveratrol (resVida®)
SOD antioxidant (Extramel®)
Amino-acid blend
Complete vitamin & mineral panel
FormatEffervescent in waterCapsule
Cost per serving (one box)~$3.30/servingOften $4–8/day
What's in the glass
The cellular-health stack, in plain English.
Branded, well-studied ingredients you can verify on the bottle. Full quantities are on the Supplement Facts panel below — no hidden proprietary blends.
01
Nicotinamide Riboside Chloride
NAD⁺ precursorA clinically studied NAD⁺ precursor — supports cellular NAD⁺ levels involved in how cells make energy.
02
Resveratrol
resVida®Branded red-grape polyphenol associated with healthy-aging research pathways.
03
Extramel® SOD
Patented antioxidantPatented melon-derived superoxide dismutase enzyme — supports antioxidant defense against oxidative stress.
04
CoQ10
Coenzyme central to mitochondrial energy production — supports cellular energy.
05
Amino-acid blend
L-Arginine, Glycine, L-Glutamine, L-Lysine, L-OrnithineA balanced amino-acid stack traditionally used by athletes for recovery and lean muscle support.
06
EGCG
Green Tea ExtractPolyphenol antioxidant that supports oxidative balance.
07
Grape Skin & Grape Seed
40% Resveratrol · 95% ProanthocyanidinsConcentrated polyphenols layered on top of resVida® for full-spectrum antioxidant support.
08
Lotus Seed Extract
U.S. Patent #5,925,348Patented botanical complex (Nelumbo Nucifera) long valued in traditional botanical nutrition.
Supplement Facts
The full label, exactly as printed.
Serving size 2 tablets · 20 servings per container. Tap below to see the complete panel with every ingredient, amount, and % Daily Value.
How it works
The routine.
Two effervescent tablets in 8 oz of water. Five days on, two days off. That's the entire protocol.
- 01
Drop two tablets in 8 oz of water
The effervescent format dissolves the actives — including the NAD precursor — into solution your stomach absorbs directly, rather than waiting on a capsule shell to break down.
- 02
5 days on, 2 days off
Take it Monday through Friday, then take a two-day break on weekends. The rhythm is what MDR doctors found keeps the body responsive to the actives.
- 03
Stack with light movement
For best results, take VitalFactors at least 30 minutes before eating, and follow with light exercise — many customers do.
Customer reviews
From people who care about cellular health — and skipped the hype.
Real reviews from verified MDR customers — pulled from the live store, prioritizing feedback about energy, recovery, and clarity.
4.7/ 5★★★★★from 16 verified customers
★★★★★VerifiedMay 2022
Product easy to use, tablet dissolves easier now, and gives me more energy and focus just after a few days of starting it!
Happy G.
★★★★★VerifiedMay 2020
I’ve been using this product for years and have never been disappointed. The product does what it says,, gives energy and vitality.
Thomas S.
★★★★★VerifiedJuly 2022
I tried out the Vital Factors to see if I could tell any difference in how I felt. I take several supplements already. After a week I could tell that I had more energy and stamina than I had been having which is one of the reasons I wanted to try it. I am now on auto-ship and looking to see if the things it says it will do actually do. But just being able to have the needed energy will keep me taking it.
Kathleen H.
★★★★★VerifiedMarch 2022
Great product! I take it in the morning before exercising and it gives me energy without the side effects other supplements do. I did prefer the old formula, as the color was purple instead of the current color, orange.
Aaron H.
★★★★★VerifiedMarch 2019
Ever since I started taking these, I feel as though I have so much more energy!
Lindsay S.
Made by Medical Doctors' Research
Made by physicians, since 1984. The opposite of a trend-chasing startup.
VitalFactors isn't a venture-backed startup — it's a forty-year-old physician-led nutrition company adding NAD support to a formula it's been refining since the mid-1980s. Every batch is manufactured to cGMP standards.
- 01Founded in 1984
- 02Doctor-formulated
- 03Manufactured to cGMP standards
- 04Used by physicians and their patients
Dr. Lisa Learn
Board-Certified Plastic & Reconstructive Surgeon
"I take VitalFactors and give it to my patients."
Safety
Nutrition, taken seriously.
VitalFactors is a nutritional formula made of vitamins, minerals, amino acids, and well-studied botanicals — not a drug — taken on a 5-on / 2-off cycle per the label. For most healthy adults it's a straightforward addition to a routine.
If you take prescription medications — especially blood thinners, diabetes medications, or hormone therapies — ask your physician or pharmacist before use. If you have kidney, liver, or gastrointestinal disease, or if you're pregnant or nursing, consult your physician first.
Contains soy isoflavones (a plant-based polyphenol). Free of gluten, dairy, eggs, fish, shellfish, tree nuts, peanuts, and animal ingredients.
Risk-free to try
One box. No traps.
Cold-traffic landing pages on the internet are notorious for sneaky checkouts. We don't do that. Here's exactly what you get.
Free shipping on subscriptions
Subscriptions ship free in the US, usually within 24 hours; one-time orders ship for $6.95.
60-day money-back guarantee
Don't feel a difference? Send it back within 60 days for a full refund of the product cost.
Cancel anytime
If you choose a subscription, cancel or pause from your account in two clicks. No phone call, no fees.
FAQ
NAD questions, answered honestly.
NAD⁺ is a coenzyme your cells use to make energy. 'NAD support' means giving the body the precursor nutrients it uses to make NAD⁺. VitalFactors uses Nicotinamide Riboside Chloride — a clinically studied precursor — as its NAD-support ingredient.
Ready when you are
The whole stack, in a glass of water.
One box is a month of NAD-supporting nutrition. Start there.
Free shipping on subscriptions · 60-day money-back guarantee · Cancel anytime.